Cytotoxic NKG2C+ CD4 T Cells Target Oligodendrocytes in Multiple Sclerosis
نویسندگان
چکیده
منابع مشابه
Cytotoxic NKG2C+ CD4 T cells target oligodendrocytes in multiple sclerosis.
The mechanisms whereby immune cells infiltrating the CNS in multiple sclerosis patients contribute to tissue injury remain to be defined. CD4 T cells are key players of this inflammatory response. Myelin-specific CD4 T cells expressing CD56, a surrogate marker of NK cells, were shown to be cytotoxic to human oligodendrocytes. Our aim was to identify NK-associated molecules expressed by human CD...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2013
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1202725